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The HIFU energy is focused sharply from the transducer surface to the targeted tissue in the prostate. Temperature is elevated in the targeted tissue up to 90 degrees C within one second causing cell death. The therapy consists of placing HIFU lesions (each requiring only a few seconds to create) side-by-side until the entire prostate gland has been "painted" with HIFU energy.

What makes HIFU unique is its precise ability to destroy diseased tissue with no effect on the surrounding structures. HIFU is non-invasive and anesthesia is not required. This treatment is often combined with radiotherapy or chemotherapy. HIFU is designed to provide the essential balance between cancer therapy and quality of life.

HIFU's ability to create high, precisely focused temperatures, allows it to have added functionality in the realm of cancer treatment. It can be used in conjunction with the targeted delivery of cancer drugs. The laser can activate temperature-sensitive liposomes filled with a cancer drug "cargo", resulting in location-specific, highly concentrated (as much as 10 times or more) doses. This results in considerably fewer side effects as the specific drug is not released system-wide.

Although the earliest widespread use of HIFU was in prostate cancer treatment, it has been successfully implemented in the treatment of cancer of the bone, brain, breast, liver, pancreas, rectum, kidney and testes.